异搏定（一种钙拮抗剂）在S期之前对淋巴细胞有丝分裂刺激的抑制作用。
Inhibition by isoptin (a calcium antagonist) of the mitogenic stimulation of lymphocytes prior to the S-phase.
作者信息
Blitstein-Willinger E, Diamantstein T
出版信息
Immunology. 1978 Feb;34(2):303-7.
Abstract
Isoptin (alpha-isopropyl-alpha-(N-methyl-N-homoveratryl)-gamma-amino-propyl-3,4-dimethoxyphenylacetonitril-hydrochloride)--a calcium antagonist--inhibits mitogenic stimulation of lymphocytes. Isoptin acts prior to the S-phase of the cehl cycle but does not prevent the early events involved in triggering of cell mitosis. The drug seems to be a good tool for studying the relevance of the 'early events' assumed to be involved in lymphocyte stimulation.
摘要
异搏定（盐酸α-异丙基-α-（N-甲基-N-高藜芦基）-γ-氨基丙基-3,4-二甲氧基苯乙腈）——一种钙拮抗剂——可抑制淋巴细胞的有丝分裂刺激。异搏定在细胞周期的S期之前起作用，但并不阻止触发细胞有丝分裂所涉及的早期事件。该药物似乎是研究假定参与淋巴细胞刺激的“早期事件”相关性的良好工具。
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