用植物血凝素处理的人淋巴细胞对放射性钙的早期摄取。
The early uptake of radioactive calcium by human lymphocytes treated with phytohaemagglutinin.
作者信息
Allwood G, Asherson G L, Davey M J, Goodford P J
出版信息
Immunology. 1971 Sep;21(3):509-16.
Abstract
Phytohaemagglutinin (PHA) is presumed to react initially with receptors on the surface of lymphocytes and may cause permeability or other changes in the lymphocyte cell membrane. The uptake of radioactive calcium (Ca) by normal human blood lymphocytes increased within 38 minutes of adding PHA, and there was little further increase in Ca uptake between 38 and 78 minutes. This effect of PHA was demonstrated at pH 7.2 and pH 7.5. There was no detectable uptake of Ca by human erythrocytes under the same conditions, with or without PHA. The observations are compatible with an early uptake of calcium when PHA initiates cell division, analogous to the role of calcium in muscle and secretory cells.
摘要
植物血凝素（PHA）被认为最初与淋巴细胞表面的受体发生反应，并可能导致淋巴细胞细胞膜的通透性或其他变化。在添加PHA后的38分钟内，正常人血淋巴细胞对放射性钙（Ca）的摄取增加，在38至78分钟之间钙摄取几乎没有进一步增加。PHA的这种作用在pH 7.2和pH 7.5时得到证实。在相同条件下，无论有无PHA，人红细胞均未检测到钙的摄取。这些观察结果与PHA启动细胞分裂时钙的早期摄取相一致，类似于钙在肌肉和分泌细胞中的作用。
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