胆囊收缩素八肽对大鼠左旋多巴行为效应的抑制作用。
Suppressive action of cholecystokinin octapeptide on the behavioral effects of L-DOPA in the rat.
作者信息
Itoh S, Katsuura G
出版信息
Eur J Pharmacol. 1981 Nov 5;75(4):313-6. doi: 10.1016/0014-2999(81)90559-8.
PMID:6274669
Abstract
Intracerebroventricular (i.c.v.) administration of cholecystokinin octapeptide (CCK-8) appeared to suppress the effects of L-DOPA and antagonize the actions of thyrotropin-releasing hormone (TRH). This was not only proved by the behavioral rating, but also by locomotor activity counting. thus, the sedative action of CCK-8 and the antagonizing effect of this peptide on the central actions of TRH were clearly demonstrated.
摘要
脑室内注射八肽胆囊收缩素（CCK-8）似乎可抑制左旋多巴的作用，并拮抗促甲状腺激素释放激素（TRH）的作用。这不仅通过行为评分得到证实，还通过运动活动计数得到证实。因此，CCK-8的镇静作用以及该肽对TRH中枢作用的拮抗作用得到了明确证明。
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