Brambilla C, Piot J M, Paramelle B
Sem Hop. 1982 Jan 7;58(1):31-4.
Ten patients with chronic respiratory failure (PaO2 = 56,19 +/- 10,54; PaCO2 = 49,17 +/- 7,31 torr) were given intramuscular injections of tiapride, Changes in alveolar ventilation were assessed clinically and by monitoring blood gases. No adverse effects were recorded. PaO2 was similar before and one hour after tiapride. There was no hypoventilation but, on the contrary, a slight decrease in PaCO2 (49,17 +/- 7,3 and 47,10 +/- 7,3 torr) and a significant increase in pH (7,358 +/- 0,023 and 7,378 +/- 0,028; p less than 0,05). Tiapride was also given to ten patients before fiberoptic bronchoscopy. Endoscopy was well tolerated in eight patients, in six there was no anxiety, and in all normal vigilance was retained.
对10例慢性呼吸衰竭患者（动脉血氧分压=56.19±10.54；动脉血二氧化碳分压=49.17±7.31托）进行了硫必利肌肉注射，通过临床评估和监测血气来评估肺泡通气的变化。未记录到不良反应。硫必利用药前和用药后1小时的动脉血氧分压相似。没有出现通气不足，相反，动脉血二氧化碳分压略有下降（49.17±7.3和47.10±7.3托），pH值显著升高（7.358±0.023和7.378±0.028；p<0.05）。在10例患者进行纤维支气管镜检查前也给予了硫必利。8例患者对内镜检查耐受良好，6例患者无焦虑情绪，所有患者均保持正常警觉。
