用高碘酸钠激活人外周血单个核细胞后诱导抑制细胞。

Induction of suppressor cells after activation of human peripheral blood mononuclear cells with sodium periodate.

作者信息

Lomnitzer R, Rabson A R

出版信息

Immunology. 1982 Jan;45(1):7-13.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555141/

Abstract

Pretreatment of normal human peripheral blood mononuclear cells (MN) with sodium periodate (NaIO4) resulted in the induction of suppressor cells. The mitogenic response of fresh allogeneic and autologous cells to phytohaemagglutinin (PHA), Concanavalin A (Con A), pokeweed mitogen (PWM), various antigens and in mixed lymphocyte culture was suppressed when NaIO4 pretreated cells were present. PWM-induced plaque-forming-cell responses were also suppressed by NaIO4-pretreated cells. Treatment of cells with mitomycin C before the NaIO4 treatment abolished the suppressive activity. A ratio of 1 : combination that resulted in the strongest suppression. Supernatants from NaIO4-pretreated cell cultures were not inhibitory.

摘要

用高碘酸钠（NaIO4）预处理正常人外周血单个核细胞（MN）可诱导抑制性细胞的产生。当存在经NaIO4预处理的细胞时，新鲜的同种异体和自体细胞对植物血凝素（PHA）、刀豆球蛋白A（Con A）、商陆有丝分裂原（PWM）、各种抗原以及混合淋巴细胞培养的促有丝分裂反应受到抑制。经NaIO4预处理的细胞也抑制PWM诱导的空斑形成细胞反应。在NaIO4处理之前用丝裂霉素C处理细胞可消除抑制活性。1: 的比例导致最强的抑制作用。来自经NaIO4预处理的细胞培养物的上清液没有抑制作用。

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本文引用的文献

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Sodium periodate-induced suppressor T cells of the human in vitro antibody response.高碘酸钠诱导的人体外抗体反应抑制性T细胞。

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Cell-to-cell interaction in the immune response. X. T-cell-dependent suppression in tolerant mice.免疫应答中的细胞间相互作用。X. 耐受小鼠中的T细胞依赖性抑制。

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Membrane site modified on induction of the transformation of lymphocytes by periodate.经高碘酸盐诱导淋巴细胞转化后修饰的膜位点

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Cell-mediated immune responses in vitro. I. Suppression of the generation of cytotoxic lymphocytes by concanavalin A and concanavalin A-activated spleen cells.体外细胞介导的免疫反应。I. 伴刀豆球蛋白A和伴刀豆球蛋白A激活的脾细胞对细胞毒性淋巴细胞生成的抑制作用。

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Role of the thymus in tolerance. X. "Suppressor" activity of antigen-stimulated rat thymocytes transferred to normal recipients.胸腺在免疫耐受中的作用。十、转移至正常受体的抗原刺激大鼠胸腺细胞的“抑制”活性。

J Immunol. 1973 May;110(5):1290-9.

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TRransformation of human lymphocytes by sodium periodate.高碘酸钠对人淋巴细胞的转化作用

Lancet. 1972 Jan 8;1(7741):103-4. doi: 10.1016/s0140-6736(72)90115-8.

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PHA-induced activation of suppressor cells in normal human peripheral blood lymphocytes.PHA诱导正常人外周血淋巴细胞中抑制细胞的激活。

Scand J Immunol. 1976;5(6-7):771-8. doi: 10.1111/j.1365-3083.1976.tb03026.x.

9

Activation of human B lymphocytes. I. Direct plaque-forming cell assay for the measurement of polyclonal activation and antigenic stimulation of human B lymphocytes.人类B淋巴细胞的激活。I. 用于测量人类B淋巴细胞多克隆激活和抗原刺激的直接空斑形成细胞测定法。

J Exp Med. 1976 Sep 1;144(3):674-84. doi: 10.1084/jem.144.3.674.

10

Activation of human B lymphocytes. VI. Immunoregulation of antibody production by mitogen-induced and naturally occurring cells in normal individuals.人B淋巴细胞的激活。VI. 正常个体中丝裂原诱导细胞和自然存在的细胞对抗体产生的免疫调节。

Cell Immunol. 1978 Mar 15;36(2):294-302. doi: 10.1016/0008-8749(78)90273-3.

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