Weissenbacher M C, Coto C E, Calello M A, Rondinone S N, Damonte E B, Frigerio M J
Infect Immun. 1982 Feb;35(2):425-30. doi: 10.1128/iai.35.2.425-430.1982.
The susceptibility of the marmoset Callithrix jacchus to Tacaribe virus infection was investigated to perform cross-protection studies between Junin and Tacaribe viruses. Five marmosets inoculated with Tacaribe virus failed to show any signs of disease, any alterations in erythrocyte, leukocyte, reticulocyte, and platelet counts or any changes in hematocrit or hemoglobin values. No Tacaribe virus could be recovered from blood at any time postinfection. Anti-Tacaribe neutralizing antibodies appeared 3 weeks postinfection. The five Tacaribe-infected marmosets and four noninfected controls were challenged with the pathogenic strain of Junin virus on day 60 post-Tacaribe infection. The former group showed no signs of disease, no viremia, and no challenge virus replication, whereas the control group exhibited the typical symptoms of Argentine hemorrhagic fever, high viremia, and viral titers in organs. Soon after challenge, the Tacaribe-protected marmosets synthesized neutralizing antibodies against Junin virus. These results indicate that the marmoset C. jacchus can be considered an experimental model for protection studies with arenaviruses and that the Tacaribe virus could be considered as a potential vaccine against Junin virus.
为了在胡宁病毒和塔卡里贝病毒之间进行交叉保护研究，对狨猴（Callithrix jacchus）感染塔卡里贝病毒的易感性进行了调查。五只接种塔卡里贝病毒的狨猴未表现出任何疾病迹象，红细胞、白细胞、网织红细胞和血小板计数未出现任何变化，血细胞比容或血红蛋白值也未改变。感染后任何时间从血液中均未分离到塔卡里贝病毒。感染后3周出现抗塔卡里贝中和抗体。在感染塔卡里贝病毒后第60天，对五只感染塔卡里贝病毒的狨猴和四只未感染的对照狨猴用胡宁病毒致病株进行攻击。前一组未表现出疾病迹象、无病毒血症且无攻击病毒复制，而对照组则表现出阿根廷出血热的典型症状、高病毒血症以及器官中的病毒滴度。攻击后不久，受塔卡里贝病毒保护的狨猴合成了针对胡宁病毒的中和抗体。这些结果表明，狨猴C. jacchus可被视为用于沙粒病毒保护研究的实验模型，并且塔卡里贝病毒可被视为一种针对胡宁病毒的潜在疫苗。
