Rägo L K, Allikmets L H, Zarkovsky A M
Naunyn Schmiedebergs Arch Pharmacol. 1981 Dec;318(1):36-7. doi: 10.1007/BF00503309.
The effects of piracetam on dopamine metabolism in rat striatal tissue and on behavioural and biochemical effects of haloperidol were studied. Piracetam in doses 600 mg/kg and 1,000 mg/kg (i.p.) increased the levels of dopamine metabolites (homovanillic acid and 3,4-dihydroxy-phenylacetic acid) but did not influence the content of dopamine in the striatum. Piracetam (1,000 mg/kg) also increased haloperidol-induced catalepsy in rats. These results are discussed in relation to the hypothesis that some behavioural effects of piracetam can be connected with its action on dopaminergic transmission.
