[Effect of certain GABA-ergic substances on dopamine metabolism in the rat brain].

Effect of the GABA-ergic drugs, sodium hydroxybutyrate, n-dipropylacetate (n-DPA) and piracetam, has been studied on the level of homovanillic acid (HVA) and activity of GABA-transaminase in the striate body of the rat brain. It has been established that piracetam in doses of 500 and 400 mg/kg, n-DPA in a dose of 200 mg/kg and sodium hydroxybutyrate in a dose of 500 mg/kg do not affect the HVA level or activity of GABA-transaminase. The data obtained are likely to support a suggestion about a possible relationship between the GABA-ergic and dopaminergic mediator system.