Malikova L A, Arefolov V A
Farmakol Toksikol. 1981 Jan-Feb;44(1):37-40.
Effect of the GABA-ergic drugs, sodium hydroxybutyrate, n-dipropylacetate (n-DPA) and piracetam, has been studied on the level of homovanillic acid (HVA) and activity of GABA-transaminase in the striate body of the rat brain. It has been established that piracetam in doses of 500 and 400 mg/kg, n-DPA in a dose of 200 mg/kg and sodium hydroxybutyrate in a dose of 500 mg/kg do not affect the HVA level or activity of GABA-transaminase. The data obtained are likely to support a suggestion about a possible relationship between the GABA-ergic and dopaminergic mediator system.
已研究了γ-氨基丁酸能药物、羟丁酸钠、二丙基乙酸钠（n-DPA）和吡拉西坦对大鼠脑纹状体中高香草酸（HVA）水平和γ-氨基丁酸转氨酶活性的影响。已确定，500和400mg/kg剂量的吡拉西坦、200mg/kg剂量的n-DPA以及500mg/kg剂量的羟丁酸钠均不影响HVA水平或γ-氨基丁酸转氨酶的活性。所获得的数据可能支持关于γ-氨基丁酸能和多巴胺能介质系统之间可能存在关系的推测。
