Knock F E, Gascoyne P R, Sylvester R, Wibel R
Physiol Chem Phys. 1981;13(4):325-33.
Immunological studies are reported showing that ascorbic acid, like selected sulfhydryl inhibitors, can induce immunity against some cancers in mice. Accompanying this immunizing action are changes in the surface structure of the cancer cells, as revealed by scanning electron microscopy. Electron spin resonance measurements show that the ascorbate anion free radical is readily produced in oxygenated cancer tissue and that this radical can react with sulfhydryl groups which are free radical scavengers. It is proposed that ascorbate acts as an effective thiolprive in oxygenated cancer tissues. This action is thought to lead to the observed changes in the cancer cell surface structure and to the concomitant immunological response.
有免疫研究报告表明，抗坏血酸与某些巯基抑制剂一样，能够在小鼠体内诱导针对某些癌症的免疫力。扫描电子显微镜显示，伴随这种免疫作用的是癌细胞表面结构的变化。电子自旋共振测量表明，抗坏血酸阴离子自由基在含氧的癌组织中很容易产生，并且该自由基可以与作为自由基清除剂的巯基发生反应。有人提出，在含氧的癌组织中，抗坏血酸充当有效的巯基剥夺剂。据认为，这种作用会导致观察到的癌细胞表面结构变化以及随之而来的免疫反应。
