Wright J P, Marks I N, Mee A S, Girdwood A H, Bornman P C, Gilinsky N H, Tobias P, Lucke W
S Afr Med J. 1982 Jan 30;61(5):155-8.
Seventy-two patients with endoscopically proven gastric ulcers were entered into a prospective controlled trial to assess the efficacy of ranitidine and cimetidine in ulcer healing. All patients were biopsied on entry and at subsequent endoscopies. After exclusion of 7 patients during the first month of treatment, the remaining 65 patients, 47 males and 18 females, mean age 48.2 +/-1.5 years, at 1 month had a healing rate of 47% and 52% respectively. The non-healers continued their treatment for a further 4 weeks. This increased the healing rate to 77% and 76% respectively. If the defaulters and poor compliers are withdrawn the healing rate rises to 58% and 57% at 4 weeks and to 91% and 79% at 8 weeks respectively. There was no significant difference between the two groups as regarded initial ulcer size and severity of dyspepsia. Antacid tablet consumption during the study was comparable. The initial size of the ulcers which failed to heal after 4 weeks of treatment tended to be larger than those which healed (P less than 0.05), but smoking did not appear to influence ulcer healing. No obvious side-effects or evidence of dysplasia were found. The study shows that ranitidine is at least as effective as cimetidine in gastric ulcer healing.
72例经内镜证实为胃溃疡的患者进入一项前瞻性对照试验，以评估雷尼替丁和西咪替丁对溃疡愈合的疗效。所有患者在入组时及随后的内镜检查时均接受活检。在治疗的第一个月排除7例患者后，其余65例患者，47例男性和18例女性，平均年龄48.2±1.5岁，1个月时的愈合率分别为47%和52%。未愈合者继续治疗4周。这使愈合率分别提高到77%和76%。如果将未复诊者和依从性差者排除，4周时愈合率分别升至58%和57%，8周时分别升至91%和79%。两组在初始溃疡大小和消化不良严重程度方面无显著差异。研究期间抗酸剂的消耗量相当。治疗4周后未愈合的溃疡初始大小往往比愈合的溃疡大（P<0.05），但吸烟似乎不影响溃疡愈合。未发现明显的副作用或发育异常迹象。该研究表明，雷尼替丁在胃溃疡愈合方面至少与西咪替丁一样有效。
