Shimokawara I, Imamura M, Yamanaka N, Ishii Y, Kikuchi K
Cancer. 1982 Apr 1;49(7):1456-64. doi: 10.1002/1097-0142(19820401)49:7<1456::aid-cncr2820490724>3.0.co;2-#.
Subpopulations of the infiltrating lymphocytes in breast cancer tissue from 31 patients were identified by indirect immunoperoxidase technique with antihuman T- and B-cell sera. In all noncancerous lesions examined (seven cases), B-cells were predominant and T-cells were scarcely found. In contrast, T-cells were predominant in breast cancer tissues (17 in 21 cases). T-cells tended to contact closely with cancer cells or cancer cell nests and accumulated around and in the walls of venules draining the cancer, while B-cells tended to cluster focally apart from cancer cell nests. T-cell infiltration was scanty in scirrhus carcinoma, whereas it was ample in infiltrating papillotubular carcinoma which had a better prognosis. There was a significant reverse correlation between the intensity of the T-cell infiltration and the clinical stages. The intensity of the T cell infiltration was significantly high in patients without lymph node metastasis. These facts suggest the possibility that the infiltrating T-cells in cancer tissue represent host resistance against cancer and that the intensity of the T cell infiltration correlates with the clinical prognosis of the breast cancer patients.
采用抗人T细胞和B细胞血清的间接免疫过氧化物酶技术，对31例乳腺癌组织中浸润淋巴细胞的亚群进行了鉴定。在所有检查的非癌性病变（7例）中，B细胞占主导，几乎未发现T细胞。相比之下，乳腺癌组织中T细胞占主导（21例中有17例）。T细胞倾向于与癌细胞或癌细胞巢紧密接触，并聚集在引流癌组织的小静脉周围及血管壁内，而B细胞则倾向于在远离癌细胞巢的局部聚集。在硬癌中T细胞浸润较少，而在预后较好的浸润性乳头状管状癌中T细胞浸润丰富。T细胞浸润强度与临床分期之间存在显著的负相关。在无淋巴结转移的患者中，T细胞浸润强度显著较高。这些事实表明，癌组织中浸润的T细胞可能代表宿主对癌症的抵抗力，且T细胞浸润强度与乳腺癌患者的临床预后相关。
