Goldenberg D M, Kim E E, DeLand F H
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7754-8. doi: 10.1073/pnas.78.12.7754.
Radioimmunodetection (RaID) of tumors containing human chorionic gonadotropin (hCG; choriogonadotropin) was evaluated in 25 patients by injecting 131I-labeled goat antibody IgG against hCG and performing total-body photoscans with a gamma scintillation camera 24 and 48 hr later. All 10 testicular cancer patients with proven tumor sites had positive RaID results, whereas three cases without known tumor were negative. Four patients with hydatidiform mole and one with degenerative products of conception showed positive RaID results consistent with elevated serum hCG titers. Two putatively false-positive results were obtained in patients with lung or ovarian cancer, whereas a false-negative metastasis to the liver of a patient with lung cancer and an elevated serum hCG titer was observed. Of 14 tumor sites found by RaID in 10 testicular cancer patients, 4 were revealed by RaID prior to any other detection method used and provided a lead time to definitive diagnosis by other measures of a few days to greater than 1 yr. Although a number of patients had high serum hCG levels, even exceeding 3 microgram/ml, the xenogeneic antibody was capable of localizing in tumor. No adverse effects were noted in any of the patients studied. Thus, hCG RaID appears to be a safe and effective method of detecting and locating hCG-producing tumors and has been found to disclose occult testicular cancers.
通过注射¹³¹I标记的抗人绒毛膜促性腺激素（hCG；绒毛膜促性腺激素）山羊抗体IgG，并在24小时和48小时后用γ闪烁相机进行全身扫描，对25例患者进行了含人绒毛膜促性腺激素肿瘤的放射免疫检测（RaID）。所有10例经证实有肿瘤部位的睾丸癌患者的RaID结果均为阳性，而3例未知肿瘤患者的结果为阴性。4例葡萄胎患者和1例妊娠退变产物患者的RaID结果呈阳性，与血清hCG滴度升高一致。肺癌或卵巢癌患者出现2例假阳性结果，而1例肺癌患者血清hCG滴度升高但肝脏有假阴性转移灶。在10例睾丸癌患者中通过RaID发现的14个肿瘤部位中，有4个在使用任何其他检测方法之前就被RaID发现，比其他检测方法明确诊断提前了几天至1年以上。尽管许多患者血清hCG水平很高，甚至超过3微克/毫升，但异种抗体仍能在肿瘤中定位。在所有研究患者中均未观察到不良反应。因此，hCG RaID似乎是一种检测和定位产生hCG肿瘤的安全有效的方法，并且已被发现可揭示隐匿性睾丸癌。
