Ingebritsen T S, Cohen P
Science. 1983 Jul 22;221(4608):331-8. doi: 10.1126/science.6306765.
Protein phosphorylation is a principal regulatory mechanism in the control of almost all cellular processes. The nature of the protein phosphatases that participate in these reactions has been a subject of controversy. Four enzymes, termed protein phosphatases 1, 2A, 2B, and 2C, account for virtually all of the phosphatase activity toward phosphoproteins involved in controlling glycogen metabolism, glycolysis, gluconeogenesis, fatty acid synthesis, cholesterol synthesis, and protein synthesis. The properties, physiological roles, and mechanisms for regulating the four protein phosphatases are reviewed.
蛋白质磷酸化是调控几乎所有细胞过程的主要调节机制。参与这些反应的蛋白质磷酸酶的性质一直是个有争议的话题。四种酶，即蛋白磷酸酶1、2A、2B和2C，几乎占了对参与控制糖原代谢、糖酵解、糖异生、脂肪酸合成、胆固醇合成和蛋白质合成的磷蛋白的所有磷酸酶活性。本文综述了这四种蛋白质磷酸酶的特性、生理作用及调节机制。
