Dean J H, Luster M I, Boorman G A, Lauer L D
Pharmacol Rev. 1982 Mar;34(1):137-48.
The discipline of immunology should provide toxicology with sensitive models to assess toxicity as well as provide better safety assessment. More information on correlations between immune function and host resistance changes and a more standardized panel of methods for immunotoxicity screening will add further credence to the already impressive immunotoxicology data base. Research efforts are needed to evaluate newer in vitro methods with microsome activation systems to screen chemicals for immunotoxicity, to evaluate chemicals for induction of hypersensitization or allergy, and to better determine whether there are chemical structure activity relationships for chemically induced immunotoxicity. The studies described here represent preliminary examples of these approaches.
免疫学学科应为毒理学提供敏感模型以评估毒性，并提供更好的安全性评估。关于免疫功能与宿主抵抗力变化之间相关性的更多信息以及一套更标准化的免疫毒性筛查方法，将进一步增强已令人瞩目的免疫毒理学数据库的可信度。需要开展研究工作来评估带有微粒体激活系统的更新的体外方法，以筛选具有免疫毒性的化学物质，评估化学物质诱导超敏反应或过敏的情况，并更好地确定化学诱导的免疫毒性是否存在化学结构-活性关系。此处描述的研究代表了这些方法的初步示例。
