Cataland S, O'Dorisio T M, Crockett S E, Mekhjian H S
J Clin Endocrinol Metab. 1978 Sep;47(3):615-9. doi: 10.1210/jcem-47-3-615.
To investigate the role of gastric inhibitory polypeptide (GIP) in the hypersecretion of glucose-stimulated insulin release in duodenal ulcer disease, serum glucose, insulin, and immunoreactive GIP (IR-GIP) were measured in 18 healthy subjects and 10 duodenal ulcer patients after glucose ingestion. Although the serum glucose and insulin were significantly greater (P less than 0.05) at 15 and 60 min in the ulcer group, the total integrated glucose areas were similar (20,552 +/- 837 vs. 19,154 +/- 745 mg-min/ml). In contrast, the total integrated insulin area was significantly greater (P less than 0.05) in the ulcer patients (12,873 +/- 2,082 vs. 8,216 +/- 1,072 micro U-min/ml). Mean IR-GIP levels were significantly greater (P less than 0.05) in the ulcer group at 15-120 min of the study, as was the total integrated area (244,755 +/- 34,934 vs. 126,595 +/- 17,468 pg-min/ml). The exaggerated insulin release to oral glucose may be due to the synergistic action of higher blood glucose and greater IR-GIP release in this disease.
为研究胃抑制性多肽（GIP）在十二指肠溃疡病患者葡萄糖刺激的胰岛素分泌过多中所起的作用，我们测定了18名健康受试者和10名十二指肠溃疡患者口服葡萄糖后血清葡萄糖、胰岛素及免疫反应性GIP（IR - GIP）的水平。尽管溃疡组在15分钟和60分钟时血清葡萄糖和胰岛素水平显著更高（P < 0.05），但总的葡萄糖积分面积相似（分别为20,552±837与19,154±745毫克·分钟/毫升）。相比之下，溃疡患者的胰岛素总积分面积显著更大（P < 0.05）（分别为12,873±2,082与8,216±1,072微单位·分钟/毫升）。在研究的15 - 120分钟内，溃疡组的平均IR - GIP水平显著更高（P < 0.05），其总积分面积也是如此（分别为244,755±34,934与126,595±17,468皮克·分钟/毫升）。在这种疾病中，口服葡萄糖后胰岛素释放过度可能是由于更高的血糖水平与更大程度的IR - GIP释放的协同作用。
