Lauritsen K B, Moody A J
Diabetologia. 1978 Mar;14(3):149-53. doi: 10.1007/BF00429773.
The response of Gastric Inhibitory Polypeptide (GIP) and insulin to a 50 g oral glucose tolerance test (OGTT) and an intravenous glucose infusion (IVGI), which copied the changes in plasma glucose concentrations during the OGTT, were measured in 10 patients with duodenal ulcer and in 10 healthy control subjects. The mean responses of GIP and insulin to OGTT were significantly increased in the ulcer patients. During IVGI the responses were normal. The degree of increased GIP response in the patients was positively correlated with the plasma glucose increase during the OGTT. It is postulated that the increased GIP secretion is related to a faster glucose absorption due to rapid gastric emptying in duodenal ulcer patients. No correlation was found between basal and peak gastric acid output and the GIP response in the patients. The data demonstrate that GIP secretion is not defective in duodenal ulcer patients.
对10例十二指肠溃疡患者和10名健康对照者进行了研究，测量了他们在口服50克葡萄糖耐量试验（OGTT）以及模拟OGTT期间血浆葡萄糖浓度变化的静脉输注葡萄糖（IVGI）过程中，胃抑制性多肽（GIP）和胰岛素的反应。溃疡患者对OGTT中GIP和胰岛素的平均反应显著增加。在IVGI期间，反应正常。患者中GIP反应增加的程度与OGTT期间血浆葡萄糖的升高呈正相关。据推测，十二指肠溃疡患者由于胃排空迅速导致葡萄糖吸收加快，从而使GIP分泌增加。患者的基础胃酸分泌量和胃酸分泌峰值与GIP反应之间未发现相关性。数据表明，十二指肠溃疡患者的GIP分泌无缺陷。
