Pollack M S, Vugrin D, Hennessy W, Herr H W, Dupont B, Whitmore W F
Cancer Res. 1982 Jun;42(6):2470-3.
The expression of HLA-A, -B, -C, and -DR antigens has been analyzed in 145 unrelated Caucasian patients with germ cell tumors of the testis. Eighteen of these patients had pure seminoma, while the remaining patients had nonseminomatous tumors with embryonal carcinoma, teratocarcinoma, choriocarcinoma, and/or yolk sac components, with or without seminoma. Increases were noted in the frequencies of Aw33, B5, DR5, and DRw6 among the patients with pure seminoma, A3 and B7 among the patients with embryonal carcinoma with or without seminoma, and Aw32 among the patients with yolk sac tumor components. A decrease in the frequency of HLA-DR3 was noted in all patients subgroups, although none of these differences were statistically significant after correction for the number of antigens tested. HLA typing results for three affected brothers of patients indicate that, in each family, the affected sibling pair share at least one HLA haplotype. The etiological and prognostic significance of this finding and of the increases in a few HLA antigen frequencies in particular patient groups and the overall decreases in DR3 remain to be determined.
对145名患有睾丸生殖细胞肿瘤的非亲属白种人患者的HLA - A、- B、- C和 - DR抗原表达进行了分析。其中18名患者患有纯精原细胞瘤，其余患者患有非精原细胞瘤，伴有胚胎癌、畸胎癌、绒毛膜癌和/或卵黄囊成分，有或无精原细胞瘤。在纯精原细胞瘤患者中，Aw33、B5、DR5和DRw6的频率增加；在有或无精原细胞瘤的胚胎癌患者中，A3和B7的频率增加；在有卵黄囊肿瘤成分的患者中，Aw32的频率增加。在所有患者亚组中均观察到HLA - DR3频率降低，尽管在校正所检测抗原数量后，这些差异均无统计学意义。对患者的三名患病兄弟进行的HLA分型结果表明，在每个家庭中，患病的同胞对至少共享一个HLA单倍型。这一发现以及特定患者组中一些HLA抗原频率增加和DR3总体频率降低的病因学和预后意义仍有待确定。
