Májský A, Abrahámová J, Korínková P, Bek V
Oncology. 1979;36(5):228-31. doi: 10.1159/000225347.
In 62 patients with testicular germinative tumours and 301 healthy unrelated subjects, 23 HLA antigens of A and B loci were tested. In the group of 40 seminomas the incidence of HLA-Bw35 antigen and in 22 patients with non-seminomas (embryonal carcinomas, teratocarcinoma and mixed forms) the frequency of HLA-A 10 antigen were significantly higher (27.50 vs. 14.28% in the controls, p greater than 0.025; 36.36 vs. 15.28%, p less than 0.025). After correction by multiplying p by the number of typed antigens there was no statistically significant result any more. The causes of dubious results of the studies about the association between HLA and malignancies are discussed.
对62例睾丸生殖细胞瘤患者和301名健康无关个体进行了23种A和B位点的HLA抗原检测。在40例精原细胞瘤患者组中，HLA - Bw35抗原的发生率，以及在22例非精原细胞瘤患者（胚胎癌、畸胎癌及混合形式）中，HLA - A10抗原的频率显著更高（对照组分别为27.50%对14.28%，p＞0.025；36.36%对15.28%，p＜0.025）。在将p乘以所检测抗原的数量进行校正后，不再有统计学显著结果。文中讨论了关于HLA与恶性肿瘤之间关联研究结果存疑的原因。
