前列腺素对诱导抗病毒细胞溶解活性的影响。
Effect of prostaglandins on elicitation of anti-viral-cytolytic activity.
作者信息
Hale A H, Evans D L, Daniel L W
出版信息
Immunol Lett. 1982 Mar;4(3):171-4. doi: 10.1016/0165-2478(82)90031-1.
We have studied the modulating effect of prostaglandins (PG) on the elicitation of secondary anti-vesicular stomatitis virus (VSV) cytotoxic T-lymphocytes (CTL) with viral antigens. The results indicate that PGE1 and PGE2 both inhibit the induction of anti-VSV CTLs by ultraviolet-inactivated VSV. Consistent with the result was the augmentation of anti-VSV CTL activity when VSV-primed spleen cells were cultured in the presence of indomethacin. These results suggest that PGs may modulate anti-viral CTL responses.
我们研究了前列腺素（PG）对病毒抗原引发继发性抗水疱性口炎病毒（VSV）细胞毒性T淋巴细胞（CTL）的调节作用。结果表明，PGE1和PGE2均抑制紫外线灭活的VSV诱导抗VSV CTL。与该结果一致的是，当在吲哚美辛存在的情况下培养经VSV致敏的脾细胞时，抗VSV CTL活性增强。这些结果表明，PG可能调节抗病毒CTL反应。
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