水泡性口炎病毒糖蛋白对于细胞毒性T淋巴细胞对感染细胞进行H-2限制性裂解是必需的。
Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted lysis of infected cells by cytotoxic T lymphocytes.
作者信息
Hale A H, Witte O N, Baltimore D, Eisen H N
出版信息
Proc Natl Acad Sci U S A. 1978 Feb;75(2):970-4. doi: 10.1073/pnas.75.2.970.
Abstract
Vesicular stomatitis virus (VSV) elicited cytotoxic thymus-derived lymphocytes (CTLs) in mice of the BALB/c and three congenic strains (BALB.b, BALB.k, BALB.HTG). CTL lysis of VSV-infected fibroblasts from the four strains was restricted by the target cells' major histocompatibility complex (H-2). Target cells were also infected with two temperature-sensitive mutants of VSV, tsM and tsG in which, respectively, the viral matrix protein and glycoprotein are not expressed at 39 degrees (restrictive temperature) on the infected cell's surface membrane. At the restrictive temperature, cells infected with wild-type VSV or tsM were lysed by CTLs, but cells infected with tsG were not. The requirement for the glycoprotein on the target cell was also evident from the ability of antisera to the glycoprotein to block completely CTL lysis of VSV-infected cells.
摘要
水泡性口炎病毒（VSV）能在BALB/c小鼠及三个同源品系（BALB.b、BALB.k、BALB.HTG）小鼠中引发细胞毒性胸腺来源淋巴细胞（CTLs）。来自这四个品系的VSV感染的成纤维细胞的CTL裂解作用受靶细胞的主要组织相容性复合体（H-2）限制。靶细胞还感染了VSV的两个温度敏感突变体，即tsM和tsG，在这两个突变体中，病毒基质蛋白和糖蛋白分别在39摄氏度（限制温度）时不在受感染细胞的表面膜上表达。在限制温度下，感染野生型VSV或tsM的细胞被CTL裂解，但感染tsG的细胞未被裂解。抗糖蛋白血清能够完全阻断VSV感染细胞的CTL裂解作用，这也证明了靶细胞上糖蛋白的必要性。
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