鼠巨细胞病毒引起的免疫抑制。
Murine cytomegalovirus-induced immunosuppression.
作者信息
Loh L, Hudson J B
出版信息
Infect Immun. 1982 Apr;36(1):89-95. doi: 10.1128/iai.36.1.89-95.1982.
Abstract
The mechanism of murine cytomegalovirus-induced immunosuppression was investigated by examining the roles played by lymphocytes and adherent cells derived from spleens of infected SWR/J mice. As few as 100 infected cells per spleen were correlated with complete abrogation of mitogen responses at 4 and 5 days after infection. In a series of cell mixing experiments it was shown that the deficiency in infected spleens was due partly to the adherent cells, which apparently secreted an immunosuppressive factor, and partly to the infected lymphocytes, which upon exposure to this factor could no longer respond to concanavalin A presented to them by normal adherent cells.
摘要
通过研究来自感染SWR/J小鼠脾脏的淋巴细胞和黏附细胞所起的作用，对鼠巨细胞病毒诱导免疫抑制的机制进行了研究。感染后4天和5天，每只脾脏中低至100个感染细胞就与丝裂原反应的完全消除相关。在一系列细胞混合实验中表明，感染脾脏中的缺陷部分归因于黏附细胞，其显然分泌一种免疫抑制因子，部分归因于感染的淋巴细胞，这些淋巴细胞在接触该因子后，不再对正常黏附细胞呈递给它们的伴刀豆球蛋白A产生反应。
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