登革病毒感染小鼠脾脏中的胸腺依赖性淋巴细胞通过前列腺素介导抑制作用。
Thymus-dependent lymphocytes of dengue virus-infected mice spleens mediate suppression through prostaglandin.
作者信息
Chaturvedi U C, Shukla M I, Mathur A
出版信息
Immunology. 1981 Jan;42(1):1-6.
Abstract
Our earlier observations indicate that adoptive transfer of spleen cells obtained from dengue type 2 virus (DV)-primed mice suppressed DV antigen-specific antibody secretion as detected by Jerne PFC technique. Findings of this paper indicate that the suppression was produced by non-glass-adherent cells, macrophage-depleted (by carbonyl iron) cells and by T lymphocytes of the spleen but not by the glass-adherent cells and B lymphocytes. The activity of these cells is dependent upon production of prostaglandin as shown by abrogation of their suppressor activity by pre-treatment of cells by indomethacin or aspirin which are known to block synthesis of prostaglandins.
摘要
我们早期的观察结果表明，从登革2型病毒（DV）致敏小鼠获得的脾细胞进行过继转移，可抑制通过耶尔内空斑形成细胞（PFC）技术检测到的DV抗原特异性抗体分泌。本文的研究结果表明，这种抑制作用是由非玻璃黏附细胞、（通过羰基铁）去除巨噬细胞后的细胞以及脾T淋巴细胞产生的，而不是由玻璃黏附细胞和B淋巴细胞产生的。这些细胞的活性依赖于前列腺素的产生，如用吲哚美辛或阿司匹林预处理细胞可消除其抑制活性所示，已知这两种药物可阻断前列腺素的合成。
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