胶原 VI 具有抗菌活性：细胞外基质的新先天宿主防御特性。
Collagen VI encodes antimicrobial activity: novel innate host defense properties of the extracellular matrix.
机构信息
Division of Infection Medicine, Department of Clinical Sciences, Biomedical Center, Lund University, Lund, Sweden.
出版信息
J Innate Immun. 2012;4(4):371-6. doi: 10.1159/000335239. Epub 2012 Mar 2.
Abstract
Collagen type VI is a subepithelial extracellular matrix component in airways and an adhesive substrate for oral pathogens [Bober et al.: J Innate Immun 2010;2:160-166]. Here, we report that collagen VI displays a dose-dependent antimicrobial activity against group A, C, and G streptococci by membrane disruption in physiological conditions. The data disclose previously unrecognized aspects of the extracellular matrix in innate host defense.
摘要
胶原 VI 是气道的上皮下细胞外基质成分，也是口腔病原体的黏附底物[Bober 等人：J Innate Immun 2010;2:160-166]。在这里，我们报告胶原 VI 在生理条件下通过破坏细胞膜表现出针对 A、C 和 G 组链球菌的剂量依赖性抗菌活性。这些数据揭示了细胞外基质在天然宿主防御中的以前未被认识的方面。
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