由柯萨奇病毒A24引起的急性出血性结膜炎疫情。

An epidemic of acute hemorrhagic conjunctivitis due to coxsackievirus A24.

作者信息

Christopher S, Theogaraj S, Godbole S, John T J

出版信息

J Infect Dis. 1982 Jul;146(1):16-9. doi: 10.1093/infdis/146.1.16.

DOI:10.1093/infdis/146.1.16

Abstract

An epidemic of acute hemorrhagic conjunctivitis in 416 (10.8%) of 3,830 staff and students of the Christian Medical College and Hospital in Vellore, India, during September-December 1979 was studied. Virus was isolated in cultures of HeLa cells from 171 of the 249 persons cultured. Most of the viral isolates were identified as an antigenic variant of coxsackievirus A24. Success in isolating the virus from conjunctival swabs was inversely proportional to the time elapsed between the onset of illness and the time the specimens were collected. In general, titers of antibody to coxsackievirus A24 were low or undetectable. Three persons had subconjunctival hemorrhage with no other symptoms, and virologic evidence of infection with coxsackievirus A24 was obtained in two of them.

摘要

1979年9月至12月期间，对印度韦洛尔基督教医学院及医院3830名教职员工和学生中的416人（10.8%）爆发的急性出血性结膜炎疫情进行了研究。从249名接受培养的人中，有171人的病毒在HeLa细胞培养物中被分离出来。大多数病毒分离株被鉴定为柯萨奇病毒A24的一个抗原变异体。从结膜拭子中分离病毒的成功率与发病到采集标本的时间间隔成反比。一般来说，抗柯萨奇病毒A24抗体滴度较低或无法检测到。三人出现结膜下出血且无其他症状，其中两人获得了感染柯萨奇病毒A24的病毒学证据。