Yin-Murphy M, Phoon M C, Chow V T
Br J Ophthalmol. 1986 Nov;70(11):869-73. doi: 10.1136/bjo.70.11.869.
A recent epidemic of acute conjunctivitis in Singapore showed again the importance of Coxsackie virus type A24 variant as a causative agent of acute haemorrhagic conjunctivitis (AHC). Although the ocular manifestations appeared similar to those described for the 1970 and 1975 outbreaks, a markedly higher rate of respiratory involvements was noted. Not observed in previous epidemics were herpes-like vesicles in the conjunctiva and eyelids of one patient and vesicles in the buccal mucosa and lips of another from whom Coxsackie virus A24 was isolated. The most interesting finding in this study was the isolation of five wild (non-Sabin) poliovirus type 1 strains. Three strains were obtained from conjunctival and two from throat swabs of patients with mild to severe conjunctivitis. It is conceivable that the rare reports of polio-like paralysis or radiculomyelitis accompanying or following AHC in a few Asian countries could be attributed to concurrent infections with a poliovirus and either enterovirus type 70 or Coxsackie virus type A24.
新加坡近期爆发的急性结膜炎疫情再次表明，A24型柯萨奇病毒变种作为急性出血性结膜炎（AHC）的病原体具有重要性。尽管眼部表现与1970年和1975年疫情中描述的相似，但呼吸道受累率明显更高。在先前的疫情中未观察到的情况是，一名患者的结膜和眼睑出现疱疹样水疱，另一名患者的颊黏膜和嘴唇出现水疱，且从后者身上分离出了A24型柯萨奇病毒。该研究中最有趣的发现是分离出了五株野生（非萨宾株）1型脊髓灰质炎病毒。三株病毒从轻度至重度结膜炎患者的结膜拭子中获得，两株从咽喉拭子中获得。可以想象，在一些亚洲国家，少数AHC患者伴有或继发类似脊髓灰质炎的麻痹或神经根脊髓炎的罕见报告，可能归因于同时感染了脊髓灰质炎病毒以及70型肠道病毒或A24型柯萨奇病毒。
