Schat K A, Calnek B W, Fabricant J, Abplanalp H
Poult Sci. 1981 Dec;60(12):2559-66. doi: 10.3382/ps.0602559.
Resistance to Marek's disease ( MD) is, in part, genetically determined and linked to the major histocompatability complex. The genetic resistance of 9 previously characterized lines of chickens and also of the inbred UCD-003 and 4 congenic lines was evaluated by challenge with JM-10. Five lines were highly resistant. These included the N-line and two derivatives from N-line (N-2 and N-5), PDRC strain, and one of the congenic UCD lines. The PDRC genotype is unknown, but the 3 related lines carry the B21 allele and the UCD line carries the BQ allele, which appears to be similar to B21. The UCD-003 and the other 3 congenic lines were moderately resistant while S-strain, P-2 and P-5 lines were highly susceptible to JM-10. The total MD incidence varied from 0 to 100% among the lines. Challenge with highly oncogenic virus isolates like GA-5, and especially the recently isolated RB-1B, caused high incidences of MD in all lines and, thus, did not permit differentiation of genetic resistance levels as was possible with the less oncogenic JM-10.
对马立克氏病（MD）的抗性部分由基因决定，并与主要组织相容性复合体相关。通过用JM - 10毒株攻毒，评估了9个先前已鉴定特征的鸡品系以及近交系UCD - 003和4个同源系的遗传抗性。有5个品系具有高度抗性。其中包括N系及其两个衍生系（N - 2和N - 5）、PDRC品系以及一个同源UCD系。PDRC的基因型未知，但3个相关品系携带B21等位基因，UCD系携带BQ等位基因，该等位基因似乎与B21相似。UCD - 003和其他3个同源系具有中等抗性，而S系、P - 2和P - 5系对JM - 10高度敏感。各品系的马立克氏病总发病率在0%至100%之间变化。用高致瘤性病毒分离株如GA - 5，尤其是最近分离的RB - 1B攻毒，在所有品系中都导致了高发病率的马立克氏病，因此，无法像用致瘤性较低的JM - 10那样区分遗传抗性水平。
