Calnek B W, Fabricant J, Schat K A, Murthy K K
Avian Dis. 1977 Jul-Sep;21(3):346-58.
To learn whether "low virulence" isolants of Marek's disease (MD) virus have a low inherent oncogenic potential, 3 isolants (CU-1, CU-2, S-11) were given to genetically susceptible S-strain or P-line birds with or without immunosuppressive treatments. Based on lesion incidence and type during an 8-10-week experimental period, embryonal (17-day) bursectomy and neonatal cyclophosphamide (CY) treatment were without effect on CU-1 and CU-2 infections in P-lines. S-11 virus was virulent for P-lines, and CY treatment reduced MD incidence as reported by others for virulent virus infections. Neonatal thymectomy or infection in ovo (at 8 days of incubation) or use of the more susceptible S-strain chicks all increased the incidence of MD induced by CU-1 and CU-2 viruses. It was concluded that the "low virulence" of these viruses is a reflection of an adequate immune response by the host.
为了解马立克氏病（MD）病毒的“低毒力”分离株是否具有较低的固有致癌潜力，将3种分离株（CU-1、CU-2、S-11）接种给具有遗传易感性的S系或P系鸡，并进行或不进行免疫抑制处理。根据8至10周实验期内的病变发生率和类型，胚胎期（17日龄）法氏囊切除术和新生雏鸡环磷酰胺（CY）处理对P系鸡感染CU-1和CU-2没有影响。S-11病毒对P系鸡具有毒力，并且CY处理降低了MD发病率，正如其他人报道的强毒病毒感染情况一样。新生雏鸡胸腺切除术、卵内感染（孵化8天时）或使用更易感的S系雏鸡均增加了CU-1和CU-2病毒诱导的MD发病率。得出的结论是，这些病毒的“低毒力”反映了宿主充分的免疫反应。
