Gelberg H B, Dieterich R A, Lewis R M
Vet Pathol. 1982 Jul;19(4):413-23. doi: 10.1177/030098588201900407.
The naturally occurring disease caused by San Miguel sea lion virus in fur seals was characterized by small fluid-filled vesicles 1 to 25 mm in diameter on the nonhaired portions of the flippers. Early epithelial lesions contained multifocal sites of cell lysis. The resultant microvesicles enlarged and coalesced, forming grossly visible macrovesicles. Mature vesicles progressed to involve all layers of the epithelium but did not involve the underlying dermis. Intradermal inoculation of vesicular exanthema of swine virus type A48 or San Miguel sea lion virus type 2 into otarid (fur) seal pups caused plaque-like lesions around inoculated coronary bands. These swellings regressed without rupture by 96 hours postinoculation. One seal inoculated with San Miguel sea lion virus had a linear lingual erosion at ten days postinoculation. Virus was isolated from this site and from two uninoculated sites, the tonsil and testicle. Contact controls showed no evidence of infection. Virus was isolated in low titers from some sites of inoculation and draining lymph nodes from seals infected with vesicular exanthema of swine virus. Virus was recovered more easily, in higher titers, and from more tissues, from seals infected with San Miguel sea lion virus. Inoculated seals tested after four to ten days seroconverted. Feeding swine seal tissues from the inoculation experiments resulted in seroconversion in swine which were fed tissues from seals infected with vesicular exanthema of swine virus but not in those which were fed tissues from seals infected with San Miguel sea lion virus.
由圣米格尔海狮病毒引起的毛皮海豹自然疾病的特征是鳍状肢无毛部分出现直径为1至25毫米的充满液体的小水泡。早期上皮病变包含多灶性细胞溶解部位。产生的微泡扩大并融合，形成肉眼可见的大泡。成熟的水泡发展至累及上皮的所有层，但不累及下方的真皮。将猪水泡疹病毒A48型或圣米格尔海狮病毒2型皮内接种到海狗（毛皮）幼崽中，在接种的冠状带周围引起斑块状病变。这些肿胀在接种后96小时消退且未破裂。一只接种圣米格尔海狮病毒的海豹在接种后十天出现线状舌部糜烂。从该部位以及两个未接种部位（扁桃体和睾丸）分离出病毒。接触对照组未显示感染迹象。从感染猪水泡疹病毒的海豹的一些接种部位和引流淋巴结中分离出低滴度的病毒。从感染圣米格尔海狮病毒的海豹中更容易以更高滴度从更多组织中回收病毒。接种后四至十天对接种的海豹进行检测，结果显示血清转化。用接种实验中的海豹组织喂养猪，喂食感染猪水泡疹病毒的海豹组织的猪出现血清转化，但喂食感染圣米格尔海狮病毒的海豹组织的猪未出现血清转化。
