Gelberg H B, Lewis R M
Vet Pathol. 1982 Jul;19(4):424-43. doi: 10.1177/030098588201900408.
Vesicular exanthema of swine virus type A48 or San Miguel sea lion virus type 2, when inoculated intradermally into swine, resulted in fluid-filled vesicles at the sites of inoculation in the snout, coronary band, and tongue. Pigs that developed vesicles also had fevers. Secondary vesicle formation varied, depending on virus serotype. Viremia was found in one pig infected with San Miguel sea lion virus five days after infection. Virus was recovered from nasal-oral passages for up to five days after infection in both groups of pigs and from the gastrointestinal and urinary tracts of pigs infected with San Miguel sea lion virus. Neutralizing antibodies began to increase three days after inoculation and reached peak titers in seven to ten days. In the absence of secondary bacterial infection, healing was well advanced by ten days after inoculation. Lesions usually were limited to nonhaired portions of the integument and tongue. Individual epithelial cells became infected when a break in the skin allowed virus access to susceptible epithelial cells from either exogenous or endogenous sources. Individual infected cells ruptured and adjacent cells were infected, resulting in the formation of multiple microvesicles. Centrifugal coalescence of microvesicles led to formation of grossly visible macrovesicles. Lesions rarely developed from viral contamination of intact hair follicles. A mild virus-induced encephalitis was seen in pigs infected with vesicular exanthema of swine virus, and virus was recovered from brain tissue of pigs infected with San Miguel sea lion virus.
猪A型48水泡疹病毒或圣米格尔海狮病毒2型经皮内接种猪后，在猪的口鼻部、冠状带和舌部接种部位会出现充满液体的水泡。出现水泡的猪也会发烧。继发水泡的形成情况各不相同，取决于病毒血清型。在一头感染圣米格尔海狮病毒的猪感染后五天发现病毒血症。两组猪在感染后长达五天都能从口鼻通道中分离出病毒，感染圣米格尔海狮病毒的猪还能从胃肠道和尿道中分离出病毒。中和抗体在接种后三天开始增加，并在七至十天达到峰值效价。在没有继发细菌感染的情况下，接种后十天伤口愈合良好。病变通常局限于皮肤和舌部的无毛部位。当皮肤破损使病毒能够从外源性或内源性来源接触易感上皮细胞时，单个上皮细胞就会被感染。单个受感染细胞破裂，相邻细胞被感染，导致形成多个微泡。微泡的离心融合导致肉眼可见的大泡形成。完整毛囊的病毒污染很少导致病变。感染猪水泡疹病毒的猪出现轻度病毒诱导的脑炎，感染圣米格尔海狮病毒的猪脑组织中可分离出病毒。
