Potter E V, Abidh S, Sharrett A R, Burt E G, Svartman M, Finklea J F, Poon-King T, Earle D P
N Engl J Med. 1978 Apr 6;298(14):767-72. doi: 10.1056/NEJM197804062981404.
To determine the incidence of chronic nephritis after poststreptococcal acute glomerulonephritis in Trinidad, 760 patients (41 adult) were examined two to six years after recovery from the illness, 344 being studied twice (four and six years). Only 1.8 per cent had persistent urine abnormalities on their last follow-up examination, and another 8.0 per cent had abnormalities that were transient or occurred only after the patient had assumed the lordotic position. In 1.4 per cent hypertension was present, whereas only one had azotemia. Both persistent urine abnormalities and hypertension increased in prevalence with age at onset of prior poststreptococcal glomerulonephritis but did not vary between sexes, races or epidemic versus endemic forms. Half the urine abnormalities present four years after recovery were absent two years later. Thus, poststreptococcal acute glomerulonephritis appears to have a low incidence of chronicity in Trinidad, with continuing resolution for more than four years.
为确定特立尼达岛链球菌感染后急性肾小球肾炎发展为慢性肾炎的发生率,对760例患者(41例成人)在病愈后两至六年进行了检查,其中344例接受了两次检查(分别在四年和六年)。在最后一次随访检查中,仅有1.8%的患者存在持续性尿液异常,另有8.0%的患者存在短暂性异常或仅在患者处于前凸位时出现异常。1.4%的患者存在高血压,仅有1例出现氮质血症。持续性尿液异常和高血压的患病率均随先前链球菌感染后肾小球肾炎发病年龄的增加而升高,但在性别、种族或流行型与散发型之间并无差异。病愈四年后出现的尿液异常,有一半在两年后消失。因此,在特立尼达岛,链球菌感染后急性肾小球肾炎发展为慢性的发生率似乎较低,多数病例在四年后仍持续缓解。