聚（ADP - 核糖）聚合酶参与培养的大鼠肝细胞中NAD损失的证据。
Evidence that poly(ADP-ribose) polymerase is involved in the loss of NAD from cultured rat liver cells.
作者信息
Paine A J, Allen C M, Durkacz B W, Shall S
出版信息
Biochem J. 1982 Feb 15;202(2):551-3. doi: 10.1042/bj2020551.
Abstract
Rat hepatocytes cultured from 24h lose 60% of their NAD content. By using the differential response to inhibitors of the two major enzymes that catabolize NAD in mammalian cells, it is shown that poly(ADP-ribose) polymerase is responsible for the loss of NAD. The relevance of this observation to the use of cultured hepatocytes for the study of DNA repair induced by carcinogens is discussed.
摘要
培养24小时的大鼠肝细胞会损失其60%的烟酰胺腺嘌呤二核苷酸（NAD）含量。通过利用对哺乳动物细胞中分解NAD的两种主要酶的抑制剂的不同反应，研究表明聚（ADP - 核糖）聚合酶是导致NAD损失的原因。本文讨论了这一观察结果与利用培养的肝细胞研究致癌物诱导的DNA修复之间的相关性。
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Nature. 1980 Feb 7;283(5747):593-6. doi: 10.1038/283593a0.
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