McNamara P J, Stoeckel K, Ziegler W H
Eur J Clin Pharmacol. 1982;22(1):71-5. doi: 10.1007/BF00606428.
The pharmacokinetic parameters of total (bound and unbound) and free (unbound) ceftriaxone in six healthy volunteers after intravenous injection of 39 were compared with low-dose data from a previous study. The dose-dependent behaviour of total drug was considerably more pronounced after the 3 gram dose. In contrast, total body clearance (C1FS = 258 ml/Min), renal clearance (C1FR = 170 ml/min) and volume of distribution (VFD (beta) = 168 1) of free (unbound) drug did not differ from the data reported earlier. There was no significant change in biological half-life (t1/2 (beta) = 7.8 h) or in the fraction excreted unchanged in urine (fu = 0.67).
将39静脉注射后，对6名健康志愿者体内总（结合型和非结合型）头孢曲松和游离（非结合型）头孢曲松的药代动力学参数与先前一项研究的低剂量数据进行了比较。3克剂量后，总药物的剂量依赖性行为更为明显。相比之下，游离（非结合型）药物的总体清除率（C1FS = 258毫升/分钟）、肾清除率（C1FR = 170毫升/分钟）和分布容积（VFD（β） = 168升）与先前报道的数据没有差异。生物半衰期（t1/2（β） = 7.8小时）或尿中以原形排泄的分数（fu = 0.67）没有显著变化。
