百日咳博德特氏菌促淋巴细胞增多因子对小脑环磷酸鸟苷水平的影响。
Effect of lymphocytosis-promoting factor from Bordetella pertussis on cerebellar cyclic GMP levels.
作者信息
Askelöf P, Gillenius P
出版信息
Infect Immun. 1982 Jun;36(3):958-61. doi: 10.1128/iai.36.3.958-961.1982.
Abstract
Dermonecrotic toxin (DNT), lipopolysaccharide (LPS), and lymphocytosis-promoting factor (LPF) were isolated from Bordetella pertussis and tested for neuroactivity. When injected intraperitoneally into rats, a dose of 0.13 mg of LPF per kg elevated the cyclic GMP level in cerebellum by approximately 70%, whereas DNT (0.5 mg/kg) and LPS (1.5 mg/kg) were without effect. This action of LPF on the central nervous system was dose dependent and did not require the administration of any additional agent, such as histamine.
摘要
从百日咳博德特氏菌中分离出皮肤坏死毒素（DNT）、脂多糖（LPS）和淋巴细胞增多促进因子（LPF），并对其神经活性进行了测试。当以每千克0.13毫克的剂量腹腔注射到大鼠体内时，LPF可使小脑环磷酸鸟苷水平升高约70%，而DNT（0.5毫克/千克）和LPS（1.5毫克/千克）则无此作用。LPF对中枢神经系统的这种作用具有剂量依赖性，并且不需要施用任何其他药剂，如组胺。
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