Gluud C, Aldershvile J, Henriksen J, Kryger P, Mathiesen L
J Clin Pathol. 1982 Jul;35(7):693-7. doi: 10.1136/jcp.35.7.693.
Sera from 74 alcoholics with cirrhosis and 63 alcoholics with steatosis were tested for antibody to hepatitis B surface antigen, to hepatitis B core antigen, and to hepatitis A virus by radioimmunoassay or enzyme-linked immunosorbent assay. No significant difference between the two groups of alcoholics could be found concerning the prevalence of these antibodies. The total group of patients had antibody to hepatitis B surface antigen or hepatitis B core antigen, or both, significantly (p less than 0.001) more often (26%) than sex- and age-matched controls (4%). No significant difference was found between patients and controls concerning the prevalence of antibody to hepatitis A virus (46% v 40%). In patients with cirrhosis, no correlation between wedged hepatic vein pressure or wedged-to-free hepatic vein pressure and any of the viral antibodies could be established. The present results suggest that hepatitis B virus does not play a major role in the progression of alcoholic liver disease, but longitudinal studies are needed to solve this problem. The reason for the increased prevalence of antibodies to hepatitis B virus in these patients is unknown.
通过放射免疫测定法或酶联免疫吸附测定法，对74名患有肝硬化的酗酒者和63名患有脂肪变性的酗酒者的血清进行了乙型肝炎表面抗原抗体、乙型肝炎核心抗原抗体和甲型肝炎病毒抗体检测。关于这些抗体的流行率，两组酗酒者之间未发现显著差异。患者总体中，乙型肝炎表面抗原抗体或乙型肝炎核心抗原抗体，或两者皆有的情况，显著（p小于0.001）多于性别和年龄匹配的对照组（4%），比例为26%。在甲型肝炎病毒抗体的流行率方面，患者和对照组之间未发现显著差异（分别为46%和40%）。在肝硬化患者中，肝静脉楔压或肝静脉楔压与自由压之间与任何一种病毒抗体之间均未建立相关性。目前的结果表明，乙型肝炎病毒在酒精性肝病的进展中不发挥主要作用，但需要进行纵向研究来解决这个问题。这些患者中乙型肝炎病毒抗体流行率增加的原因尚不清楚。
