Alberghina M, Viola M, Giuffrida A M
J Neurosci Res. 1982;7(2):147-54. doi: 10.1002/jnr.490070206.
Hypoxic treatment causes changes of some enzymatic activities involved in the glycerolipid metabolism in subcellular fractions of guinea pig cerebral hemispheres. The activity of lysophosphatidylcholine acyltransferase, choline phosphotransferase, glycerol-3-phosphate acyltransferase(s), as well as the activity of triacylglycerol lipase significantly decreased in the microsomes of cerebral hemispheres of animals intermittently exposed to hypoxic treatment for eighty hours. At the same time, a marked activation of microsomal and mitochondrial phospholipase A2 occurred. The changes of the above-mentioned enzymatic activities after the hypoxic treatment correlated well with the increase in the level of brain and blood free fatty acids. The changes also correlated with the decrease of labeled lipid precursors incorporated into lipids of the cerebral hemispheres, observed during oxygen insufficiency.
缺氧处理会导致豚鼠大脑半球亚细胞组分中参与甘油脂质代谢的一些酶活性发生变化。在间歇性接受80小时缺氧处理的动物大脑半球微粒体中，溶血磷脂酰胆碱酰基转移酶、胆碱磷酸转移酶、甘油-3-磷酸酰基转移酶的活性以及三酰甘油脂肪酶的活性均显著降低。与此同时，微粒体和线粒体磷脂酶A2出现明显激活。缺氧处理后上述酶活性的变化与脑和血液中游离脂肪酸水平的升高密切相关。这些变化还与缺氧期间观察到的大脑半球脂质中标记脂质前体掺入量的减少相关。
