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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Whiting P H, Bowley M, Sturton R G, Pritchard P H, Brindley D N, Hawthorne J N

Biochem J. 1977 Nov 15;168(2):147-53. doi: 10.1042/bj1680147.

Rats were injected with a single dose of 35mg of streptozotocin/kg body wt. They exhibited a diabetes that was characterized by glycosuria, polyuria, polydipsia, hyperphagia, hyperglycaemia, increased concentrations of unesterified fatty acids, glycerol and triacylglycerols in the serum and an increased activity of glucose 6-phosphatase in the liver. 2. After 10 weeks the hepatic activities of the microsomal glycerol phosphate acyltransferase, phosphatidate phosphohydrolase, phosphatidate cytidylyltransferase, diacylglycerol acyltransferase, choline phosphotransferase, CDP-diacylglycerol--inositol phosphatidyltransferase and the soluble phosphatidate phosphohydrolase were measured. 3. The only significant changes were an increase in the activity of the soluble phosphatidate phosphohydrolase and a decrease in that of the CDP-diacylglycerol--inositol phosphatidyltransferase in the diabetic rats. 4. These results are discussed in relation to the control of glycerolipid synthesis.

给大鼠注射单剂量35毫克/千克体重的链脲佐菌素。它们出现了糖尿病，其特征为糖尿、多尿、多饮、食欲亢进、高血糖、血清中未酯化脂肪酸、甘油和三酰甘油浓度升高以及肝脏中葡萄糖6-磷酸酶活性增加。2. 10周后，测定微粒体甘油磷酸酰基转移酶、磷脂酸磷酸水解酶、磷脂酸胞苷酰转移酶、二酰甘油酰基转移酶、胆碱磷酸转移酶、CDP-二酰甘油 - 肌醇磷脂酰转移酶以及可溶性磷脂酸磷酸水解酶的肝脏活性。3. 唯一显著的变化是糖尿病大鼠中可溶性磷脂酸磷酸水解酶活性增加，而CDP-二酰甘油 - 肌醇磷脂酰转移酶活性降低。4. 结合甘油脂质合成的调控对这些结果进行了讨论。

Whiting P H, Bowley M, Sturton R G, Pritchard P H, Brindley D N, Hawthorne J N

Biochem J. 1977 Nov 15;168(2):147-53. doi: 10.1042/bj1680147.

Rats were injected with a single dose of 35mg of streptozotocin/kg body wt. They exhibited a diabetes that was characterized by glycosuria, polyuria, polydipsia, hyperphagia, hyperglycaemia, increased concentrations of unesterified fatty acids, glycerol and triacylglycerols in the serum and an increased activity of glucose 6-phosphatase in the liver. 2. After 10 weeks the hepatic activities of the microsomal glycerol phosphate acyltransferase, phosphatidate phosphohydrolase, phosphatidate cytidylyltransferase, diacylglycerol acyltransferase, choline phosphotransferase, CDP-diacylglycerol--inositol phosphatidyltransferase and the soluble phosphatidate phosphohydrolase were measured. 3. The only significant changes were an increase in the activity of the soluble phosphatidate phosphohydrolase and a decrease in that of the CDP-diacylglycerol--inositol phosphatidyltransferase in the diabetic rats. 4. These results are discussed in relation to the control of glycerolipid synthesis.

给大鼠注射单剂量35毫克/千克体重的链脲佐菌素。它们出现了糖尿病，其特征为糖尿、多尿、多饮、食欲亢进、高血糖、血清中未酯化脂肪酸、甘油和三酰甘油浓度升高以及肝脏中葡萄糖6-磷酸酶活性增加。2. 10周后，测定微粒体甘油磷酸酰基转移酶、磷脂酸磷酸水解酶、磷脂酸胞苷酰转移酶、二酰甘油酰基转移酶、胆碱磷酸转移酶、CDP-二酰甘油 - 肌醇磷脂酰转移酶以及可溶性磷脂酸磷酸水解酶的肝脏活性。3. 唯一显著的变化是糖尿病大鼠中可溶性磷脂酸磷酸水解酶活性增加，而CDP-二酰甘油 - 肌醇磷脂酰转移酶活性降低。4. 结合甘油脂质合成的调控对这些结果进行了讨论。