克隆的人干扰素对单纯疱疹病毒复制及诱导的细胞融合的影响。
Effect of cloned human interferons on the replication of and cell fusion induced by herpes simplex virus.
作者信息
Chatterjee S, Lakeman A D, Whitley R J, Hunter E
出版信息
Virus Res. 1984 Jan;1(1):81-7. doi: 10.1016/0168-1702(84)90037-6.
PMID:6099653
Abstract
Human alpha- and beta-interferons, expressed from cloned genes, block the replication of, and cell fusion induced by herpes simplex viruses. This inhibition is neutralized by antiserum to interferon and demonstrates species specificity. The block in replication appears to be late in the replication cycle of herpes simplex virus, since similar levels of viral DNA are synthesized in both interferon-treated and untreated cells.
摘要
从克隆基因表达的人α-和β-干扰素可阻断单纯疱疹病毒的复制以及由其诱导的细胞融合。这种抑制作用可被抗干扰素血清中和，并表现出种属特异性。复制阻断似乎发生在单纯疱疹病毒复制周期的后期，因为在干扰素处理和未处理的细胞中合成的病毒DNA水平相似。
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