Liberman E A, Minina S V, Shklovsky-Kordy N E, Conrad M
Biosystems. 1982;15(2):127-32. doi: 10.1016/0303-2647(82)90026-0.
Cyclic 3',5'-AMP and cyclic 3',5'-GMP injected into large neurons of the snail Helix lucorum altered neuron activity. The effect of cAMP is usually depolarizing and that of cGMP hyperpolarizing. The results are specific for 3',5'-cyclic nucleotides. The experiments support the hypothesis that reaction-diffusion processes involving cyclic nucleotides form the basis of an intraneuronal system of information processing.
向蜗牛亮大蜗牛的大型神经元中注射环3',5'-腺苷酸（cAMP）和环3',5'-鸟苷酸（cGMP）会改变神经元活动。cAMP的作用通常是使膜电位去极化，而cGMP的作用是使膜电位超极化。这些结果对3',5'-环核苷酸具有特异性。这些实验支持了这样一种假说，即涉及环核苷酸的反应扩散过程构成了神经元内信息处理系统的基础。
