Ikeda K, Suita S, Nakagawara A, Takabayashi K
Arch Surg. 1979 Feb;114(2):203-7. doi: 10.1001/archsurg.1979.01370260093016.
In two children with hepatoblastoma, response to chemotherapy permitted subsequent surgical resection. Initially, in both patients, the tumor was thought to be unresectable because of size and/or extent. Chemotherapy with vincristine sulfate and cyclophosphamide resulted in substantial reduction in tumor size, and laparotomy for excision was performed after nine months and four months of therapy, respectively. In case 1, the tumor was localized in the right hepatic lobe and the right hepatic lobectomy was performed. In case 2, the tumor was located in both right and left lobes, but was encapsulated and it was possible to enucleate the tumor with complete gross excision. Both children are living and well without evidence of recurrence of tumor 11 and 23 months after operation.
在两名肝母细胞瘤患儿中，化疗反应使后续手术切除成为可能。最初，两名患者的肿瘤均因大小和/或范围被认为无法切除。硫酸长春新碱和环磷酰胺化疗使肿瘤大小大幅缩小，分别在治疗9个月和4个月后进行了剖腹切除术以切除肿瘤。病例1中，肿瘤位于右肝叶，实施了右肝叶切除术。病例2中，肿瘤位于左右两叶，但有包膜，可行肿瘤剜除术并实现大体完整切除。两名患儿均存活良好，术后11个月和23个月均无肿瘤复发迹象。
