感染诺沃克病毒、雪山病毒或夏威夷病毒的成年人针对重组诺沃克病毒衣壳抗原（rNV）的亚类特异性血清抗体反应。
Subclass-specific serum antibody responses to recombinant Norwalk virus capsid antigen (rNV) in adults infected with Norwalk, Snow Mountain, or Hawaii virus.
作者信息
Treanor J J, Jiang X, Madore H P, Estes M K
机构信息
Infectious Diseases Unit, University of Rochester, New York 14642.
出版信息
J Clin Microbiol. 1993 Jun;31(6):1630-4. doi: 10.1128/jcm.31.6.1630-1634.1993.
Subclass-specific antibody responses to the Norwalk virus capsid protein in adults challenged with Norwalk, Snow Mountain, or Hawaii virus were evaluated by solid-phase enzyme immunoassay using recombinant Norwalk virus capsid antigen (rNV). Fourfold or greater serum immunoglobulin G (IgG) antibody responses to rNV were detected in 15 of 20 volunteers challenged with Norwalk virus, and serum IgA and IgM antibody responses to rNV were seen in almost all subjects who had rNV IgG responses. Serum rNV IgG antibody responses also were detected in 6 of 15 volunteers challenged with Snow Mountain virus and 2 of 12 volunteers challenged with the Hawaii virus. However, the magnitude of antibody response and the geometric mean postchallenge rNV IgG antibody titers were lower in subjects challenged with Snow Mountain or Hawaii virus, and serum IgA and IgM responses generally did not occur.
采用重组诺如病毒衣壳抗原（rNV），通过固相酶免疫测定法评估了感染诺如病毒、雪山病毒或夏威夷病毒的成年人体内针对诺如病毒衣壳蛋白的亚类特异性抗体反应。在20名感染诺如病毒的志愿者中，有15人检测到对rNV的血清免疫球蛋白G（IgG）抗体反应升高四倍或更高，并且几乎所有出现rNV IgG反应的受试者都出现了血清IgA和IgM抗体反应。在15名感染雪山病毒的志愿者中，有6人检测到血清rNV IgG抗体反应，在12名感染夏威夷病毒的志愿者中，有2人检测到血清rNV IgG抗体反应。然而，感染雪山病毒或夏威夷病毒的受试者的抗体反应强度以及激发后rNV IgG抗体滴度的几何平均值较低，并且一般未出现血清IgA和IgM反应。
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