Walker D H, Johnson K M, Lange J V, Gardner J J, Kiley M P, McCormick J B
J Infect Dis. 1982 Sep;146(3):360-8. doi: 10.1093/infdis/146.3.360.
As a model for the pathogenesis of Lassa fever in humans, nine rhesus monkeys were inoculated with Lassa virus. Three monkeys had had a previous asymptomatic experimental infection with Mozambique virus, a closely related arenavirus; these monkeys were protected from illness and viremia and manifested only mild pathologic lesions. The other animals developed severe disease and viremia. At necropsy, hepatocellular necrosis, interstitial pneumonia, a unique pulmonary arteritis, adrenal gland necrosis, encephalitis, and uveitis were prominent pathologic lesions which correlated with the organ titers of virus. One animal infected with Lassa virus developed prolonged viremia, a typical immune response, and sudden onset of lower limb paralysis after recovery; at necropsy chronic proliferative arteritis of the spinal cord, brain, and heart was evident. Similarities and differences in the pathologic lesions in this model and Lassa fever in humans indicate that care must be taken in interpreting the results of experiments concerning immune prophylaxis, pathogenesis, and treatment in rhesus monkeys.
作为人类拉沙热发病机制的模型，9只恒河猴接种了拉沙病毒。其中3只猴子先前曾无症状感染莫桑比克病毒，这是一种密切相关的沙粒病毒；这些猴子未患病且无病毒血症，仅表现出轻微的病理损伤。其他动物则出现了严重疾病和病毒血症。尸检时，肝细胞坏死、间质性肺炎、一种独特的肺动脉炎、肾上腺坏死、脑炎和葡萄膜炎是与病毒器官滴度相关的突出病理损伤。一只感染拉沙病毒的动物出现了持续的病毒血症、典型的免疫反应，并在康复后突然出现下肢麻痹；尸检时，脊髓、脑和心脏的慢性增殖性动脉炎明显。该模型与人类拉沙热病理损伤的异同表明，在解释恒河猴免疫预防、发病机制和治疗实验结果时必须谨慎。
