人表达的母乳增强猴肾细胞系中人轮状病毒的感染性

Enhancement of human rotavirus infectivity in a monkey kidney cell line by human expressed breast milk.

作者信息

Totterdell B M, MacLeod J, Chrystie I L, Banatvala J E

出版信息

J Med Virol. 1982;9(4):307-10. doi: 10.1002/jmv.1890090409.

Abstract

Eight of forty (20%) human expressed breast milks enhanced the infectivity of human rotavirus (HRV) when assayed by immunofluorescence in a monkey kidney cell line (LLC-MK2). This enhancement was demonstrated with two HRV strains, one derived from a fecal specimen of a child with acute gastroenteritis, the other a tissue culture adapted strain. The phenomenon could have important implications in the pathogenesis of HRV infections and in future vaccine programs.

摘要

在猴肾细胞系（LLC-MK2）中通过免疫荧光法检测时，40份人源母乳中有8份（20%）增强了人轮状病毒（HRV）的感染性。两种HRV毒株均证实了这种增强作用，一种源自一名急性胃肠炎患儿的粪便标本，另一种是组织培养适应株。这种现象可能对HRV感染的发病机制以及未来的疫苗计划具有重要意义。