Sasagawa A, Miyamura K, Kono R
Jpn J Med Sci Biol. 1982 Apr;35(2):63-73. doi: 10.7883/yoken1952.35.63.
The neutralizing activity against human enterovirus type 70 was found in serum samples from normal cattle, horses, sheep, goats, swine and chickens raised in Japan. The frequency was variable depending upon animal species and the year of bleeding. The neutralizing activity in bovine sera was shown to reside in IgM by sucrose gradient centrifugation and immune gel electrophoresis. These findings suggested that the neutralizing substance in domestic animal sera is the antibody of IgM class elicited by unidentified viruses antigenically related to human enterovirus type 70.
在日本饲养的正常牛、马、羊、山羊、猪和鸡的血清样本中发现了针对人肠道病毒70型的中和活性。其频率因动物种类和采血年份而异。通过蔗糖梯度离心和免疫凝胶电泳表明，牛血清中的中和活性存在于IgM中。这些发现表明，家畜血清中的中和物质是由与人类肠道病毒70型抗原相关的未知病毒引发的IgM类抗体。
