Benit C, Picard M, Brion N, Robin P M, Delavierre P, Friocourt P, Picard R
Sem Hop. 1982 Jun 3;58(22):1383-7.
The term cryptic miliary tuberculosis designates a particular form of hematogenous tuberculosis in which the usual diagnostic criteria, especially the roentgenographic ones, are lacking. Two cases are reported. Initial clinical manifestations were prolonged fever, poor general condition, low blood pressure, low serum sodium, mild hepatic biological disorders, and myocarditis. No other radiological or biological features, suggestive of tuberculosis were found. In the first patient, the various visceral tuberculous localizations occurred under specific treatment, although the latter was otherwise effective. In the second patient, they were identified by pathological examination. The incidence of these occult forms of tuberculosis, where diagnosis is often established too late, and sometimes only postmortem, is not negligible. This possibility must be borne in mind in severe infectious conditions without obvious etiology, particularly when the following features are present : inadequate secretion of ADH, which often indicates latent encephalitic and meningitic involvement where CSF anomalies may be incomplete or lacking ; leucopenia or pancytopenia ; biological hepatic anomalies ; exceptionally, such as in the two cases described, cardiac involvement. Among diagnostic procedures, liver biopsy is of the utmost importance. Mere diagnostic presumption is sufficient to warrant initiation of antituberculous therapy. This ensures survival and, paradoxically, allows delayed overt clinical manifestations to develop.
隐匿性粟粒性肺结核这一术语指的是血行播散型肺结核的一种特殊形式,其缺乏通常的诊断标准,尤其是影像学诊断标准。本文报告了两例病例。初始临床表现为长期发热、全身状况差、低血压、低血钠、轻度肝脏生化指标异常及心肌炎。未发现其他提示结核病的影像学或生物学特征。在首例患者中,尽管特异性治疗有效,但各种内脏结核定位仍在治疗过程中出现。在第二例患者中,通过病理检查确诊。这些隐匿型肺结核的发病率不容忽视,其诊断往往过晚,有时甚至仅在尸检时才得以确诊。在病因不明的严重感染性疾病中,尤其当出现以下特征时,必须考虑到这种可能性:抗利尿激素分泌不足,这往往提示潜在的脑实质和脑膜受累,此时脑脊液异常可能不完整或缺乏;白细胞减少或全血细胞减少;肝脏生化指标异常;如本文所述的两例病例,罕见的心脏受累。在诊断方法中,肝活检至关重要。仅凭诊断推测就足以启动抗结核治疗。这既能确保患者存活,而且矛盾的是,还能使延迟出现的明显临床表现得以显现。