Maxon H R, Burman K D, Premachandra B N, Chen I W, Burger A, Levy P, Georges L P
Acta Endocrinol (Copenh). 1982 Jun;100(2):224-30. doi: 10.1530/acta.0.1000224.
Elevations of serum thyroxine without thyrotoxicosis or binding protein abnormalities have been documented in 8 of 13 family members, representing 4 generations. This syndrome appears to represent an elevated threshold for the amount of free thyroxine substrate required to maintain adequate T3 production form the peripheral monodeiodination of T4. It reiterates the need for a prudent re-evaluation of all clinically euthyroid patients with elevated serum thyroxine concentrations before concluding that they are indeed thyrotoxic.
在13名家族成员（代表4代人）中，有8人血清甲状腺素升高，但无甲状腺毒症或结合蛋白异常。这种综合征似乎代表了维持足够的T3从T4外周单碘化产生所需的游离甲状腺素底物量的阈值升高。这再次强调，在得出临床甲状腺功能正常的患者确实存在甲状腺毒症的结论之前，需要谨慎地重新评估所有血清甲状腺素浓度升高的患者。
