Bichel P, Poulsen H S, Andersen J
Cancer. 1982 Nov 1;50(9):1771-4. doi: 10.1002/1097-0142(19821101)50:9<1771::aid-cncr2820500921>3.0.co;2-7.
In 46 cases of invasive ductal mammary carcinoma the relationship between estrogen receptor (ER) content and ploidy was investigated. Seventy-one percent of the diploid tumors were ER+ against 40% ER+ tumors in the nondiploid group. Forty percent of the ER+ cases had nondiploid tumors and in several of these more than one tumor cell population could be demonstrated. The results support the hypothesis that multiclonal or mosaic composition of the tumor may explain why 30-45% of the patients with apparently ER+ tumors do not respond to endocrine therapy.
在46例浸润性导管乳腺癌病例中，研究了雌激素受体（ER）含量与倍体之间的关系。二倍体肿瘤中有71%为ER阳性，而非二倍体组中ER阳性肿瘤占40%。40%的ER阳性病例有非二倍体肿瘤，其中有几例可显示出不止一种肿瘤细胞群。这些结果支持了这样一种假说，即肿瘤的多克隆或镶嵌组成可能解释了为什么30%-45%表面上ER阳性的肿瘤患者对内分泌治疗无反应。
