Suehiro S, Hamada Y, Toi M, Nakamura T, Niimoto M, Hattori T
Department of Surgery, Hiroshima University, Japan.
Jpn J Surg. 1990 Jan;20(1):115-8. doi: 10.1007/BF02470724.
Nuclear DNA ploidy pattern was examined in 22 breast carcinomas with a tumor mass of up to 2.2 cm and compared with the clinical and histological parameters of the malignant potentiality of breast carcinomas. The 22 carcinomas were divided into 11 aneuploid and 11 near-diploid carcinomas. It was found that the histological type, histological grade, nuclear grade, mitotic index and lymphatic invasion were either only slightly, or not correlated at all with the DNA ploidy pattern. Nevertheless, lymph node metastasis and negative estrogen receptor status was more frequently seen in the patients with aneuploid carcinoma than in those with near-diploid carcinoma.
对22例肿瘤肿块最大达2.2 cm的乳腺癌进行了核DNA倍体模式检测，并与乳腺癌恶性潜能的临床和组织学参数进行了比较。这22例癌被分为11例非整倍体癌和11例近二倍体癌。结果发现，组织学类型、组织学分级、核分级、有丝分裂指数和淋巴浸润与DNA倍体模式要么仅有轻微关联，要么完全无关联。然而，非整倍体癌患者比近二倍体癌患者更常出现淋巴结转移和雌激素受体阴性状态。
