Rothstein G, Clarkson D R, Larsen W, Grosser B I, Athens J W
N Engl J Med. 1978 Jan 26;298(4):178-80. doi: 10.1056/NEJM197801262980402.
We measured the effect of lithium on the blood neutrophil mass and neutrophil production, using standard di-isopropylfluorophosphate (DF32P) methods. In 12 lithium-treated patients the total blood neutrophil pool was 105 (42 to 270) x 10(7) cells per kilogram (median and 95 per cent limits) as compared with 61 (27 to 138 x 10(7) in 71 controls (P less than 0.001). The neutrophil turnover rate, a measure of effective neutrophil production, was 230 (108 to 380) x 10(7) cells per kilogram per day in the lithium-treated group and 160 (62 to 400) x 10(7) in the controls (P less than 0.05). Neutrophil migration into skin lesions ranged from 34 to 469 x 10(5) cells per day in the lithium-treated patients, as compared with 1.7 to 68 x 10(5) in 10 controls. Lithium causes enlargement of the total circulating neutrophil mass and accelerates neutrophil production without impairing neutrophil migration into skin lesions.
我们采用标准的二异丙基氟磷酸酯（DF32P）方法，测定了锂对血液中性粒细胞数量及中性粒细胞生成的影响。12例接受锂治疗的患者，其全血中性粒细胞池为每千克105（42至270）×10⁷个细胞（中位数及95%范围），而71例对照者为61（27至138）×10⁷个细胞（P<0.001）。中性粒细胞周转率是有效中性粒细胞生成的一项指标，锂治疗组为每千克每天230（108至380）×10⁷个细胞，对照组为160（62至400）×10⁷个细胞（P<0.05）。锂治疗患者中性粒细胞向皮肤损伤处的迁移量为每天34至469×10⁵个细胞，而10例对照者为1.7至68×10⁵个细胞。锂可使循环中的中性粒细胞总量增加，并加速中性粒细胞生成，而不影响中性粒细胞向皮肤损伤处的迁移。
