Wilkes S R, Gragoudas E S
Ophthalmology. 1982 Jul;89(7):840-4. doi: 10.1016/s0161-6420(82)34731-4.
Forty-four uveal melanomas were evaluated for patterns of tumor regression after proton beam irradiation. All tumors were followed for a minimum of ten months after treatment. Seven lesions completely disappeared, 33 have decreased in size, and 4 remained unchanged. Associated signs of tumor regression were: resolution of the secondary serous retinal detachments, central apical yellow discoloration of the tumor, destruction of the tumor's vasculature, and elimination of fluorescein leakage. This study demonstrated that regression after proton beam irradiation is a relatively slow process, and the effects of radiation could be observed in some cases more than a year after treatment.
对44例葡萄膜黑色素瘤进行了质子束照射后肿瘤消退模式的评估。所有肿瘤在治疗后至少随访10个月。7个病灶完全消失，33个病灶大小减小，4个病灶保持不变。肿瘤消退的相关征象包括：继发性浆液性视网膜脱离消退、肿瘤中心顶端黄色变色、肿瘤血管系统破坏以及荧光素渗漏消失。本研究表明，质子束照射后的消退是一个相对缓慢的过程，在某些病例中，治疗一年多后仍可观察到放疗效果。
