Brown M R, Fisher L A, Spiess J, Rivier J, Rivier C, Vale W
Regul Pept. 1982 Jul;4(2):107-14. doi: 10.1016/0167-0115(82)90101-x.
Corticotropin-releasing factor (CRF), a peptide isolated from ovine hypothalamus, and sauvagine, a peptide isolated from frog skin, share significant structural homology and elicit a number of similar biological responses. CRF is more potent than sauvagine in stimulating pituitary ACTH secretion. Sauvagine, however, is 5-10 times more potent than CRF to act within the brain to increase plasma levels of catecholamines and glucose and to elevate mean arterial pressure. Sauvagine is likewise more potent than CRF to act outside the brain to increase superior mesenteric artery flow and plasma glucose concentrations and to decrease mean arterial pressure. CRF and sauvagine produce important effects representative of biologically active peptides.
促肾上腺皮质激素释放因子（CRF）是一种从绵羊下丘脑分离出的肽，而蛙皮素是一种从蛙皮分离出的肽，它们具有显著的结构同源性，并引发许多相似的生物学反应。在刺激垂体促肾上腺皮质激素（ACTH）分泌方面，CRF比蛙皮素更有效。然而，在大脑内发挥作用以提高血浆儿茶酚胺和葡萄糖水平并升高平均动脉压方面，蛙皮素比CRF强5至10倍。在大脑外发挥作用以增加肠系膜上动脉血流量和血浆葡萄糖浓度并降低平均动脉压方面，蛙皮素同样比CRF更有效。CRF和蛙皮素产生了代表生物活性肽的重要作用。
